Diabetes, protein that causes kidney loss, identified

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This is according to the results of a recent study, the result of a collaboration between the Joslin Diabetes Center in Boston, Harvard Medical School, Boston Children’s Hospital and the Romeo and Enrica Invernizzi Pediatric Research Center at the State University of Milan.

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Diabetes is known to seriously affect the kidneys, which in some cases can lead to chronic renal failure. A recent study, the result of a collaboration between the Joslin Diabetes Center in Boston, Harvard Medical School, Boston Children’s Hospital and the Romeo and Enrica Invernizzi Pediatric Research Center at Milan State University, shed light on this consequence of the pathology. . Researchers identified Nbl1 (Neuroblastoma suppressor of tumorigenicity 1) as the factor responsible for the loss of kidney function. At high concentrations, this protein exerts a toxic effect on kidney cells. This information, hitherto unknown, could be useful to identify patients most at risk for chronic renal failure and to develop new therapies that target Nbl1. The research results have been published in the journal Science Translational Medicine.

The discoveries of the researchers

Thanks to the study, the researchers were able to discover that elevated Nbl1 levels in the blood are associated with the risk of premature loss of kidney function, both in patients with juvenile type 1 diabetes and in patients with type 2 diabetes. The loss of podocytes in the kidney glomeruli , confirmed both by the analysis of tissues from diabetic patients and by experiments in test tubes. “The discovery of the role of Nbl1 not only has strong prognostic value, but is also of great importance in understanding the mechanisms leading to the development of one of the most common complications of diabetes in the world, namely diabetic nephropathy” . This is explained by Paolo Fiorina, professor of endocrinology and director of the International Research Center on Type 1 Diabetes at the Romeo and Enrica Invernizzi Pediatric Research Center”.

“For the first time, we have identified a toxic factor that targets renal podocytes, demonstrating that not only does hyperglycemia cause real harm, but there are specific factors that could be a potential target for future therapies.”

Source: TG 24 Sky

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